1980 The Diagnostic Systems Branch was created to pursue research and development of noninvasive diagnostic techniques, and analysis of the functional development of the oral and pharyngeal region. This article introduces the new NIDCR initiative in general dentistry practice-based research. NIDR conducted more than 30 focus groups with professional organizations, NIDR staff, specialty groups, and the public toward the development of a new institute strategic plan. NIDCR provides leadership for a national research program designed to understand, treat, and ultimately prevent the infectious and inherited craniofacial-oral-dental diseases and disorders that compromise millions of human lives. Artificial replacement will never do the job as well.". To emphasize anesthesia-analgesia dental problems, the NIDR reorganized its intramural program to form a Neurobiology and Anesthesiology Branch composed of the neural mechanism section and the anesthesiology section. Some studies even suggest that stem cells from teeth could be used to create bone marrow or treat Alzheimers and Parkinsons diseases. 1995 NIDR sponsored "Partnerships in Communication: A Meeting of Dental Editors," which brought together for the first time at NIH more than 30 editors and executive directors of dental organizations to enhance communication among the group. This board was established to provide advice to NIDR on matters of general policy, particularly from a long-range viewpoint, as they relate to the intramural program. Investing in a Cure for Sickle Cell Disease: Lakshmanan Krishnamurti, M.D.